Principal Scientist, Pharmacology (In Vivo PK/Tox)

04 Nov 2024

Vacancy expired!

Job Description

Exelixis is seeking a highly self-motivated, interactive, and productive Principal Scientist to join Discovery working towards discovery of anti-cancer agents for the treatment of targeted indications. The successful candidate will be a creative scientist with a strong desire to succeed at the highest level. This individual will have strong knowledge and experience in Discovery, Nonclinical Pharmacokinetics and Toxicology in small molecular and can characterize the toxicology profiles of lead compounds and provide input into investigative studies and clinical starting dose strategies. This position will have shared responsibility for the management and development of the Discovery laboratory as part of the In Vivo Tox/PK team.

Qualifications

ESSENTIAL DUTIES AND RESPONSIBILITIES: Design, execute and analyze in vivo PK and Tox experiments to test the selected compounds in multi-species models. Serve as the Toxicology lead and subject matter expert to engage cross-functional teams to interpret data from non-clinical toxicology and PK studies in developing small molecular anti-cancer drugs. Establish PK/PD relationship; characterize toxicity profile for the preclinical therapeutic candidates. Lead investigative efforts into mechanisms of toxicity; and develop issue mitigation and resolution strategies for toxicities observed in vivo. Utilize literature and internal data sets to design and test hypotheses for drug targets. Present Toxicology/PK/TK-related data to internal project teams and senior management. Provide scientific support for the project teams and Discovery staffs. Prepare technical reports for research findings and IND filings. Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.SUPERVISORY RESPONSIBILITIES: Supervises staff, including hiring, scheduling and assigning work, reviewing performance, andrecommends salary increases, promotions, transfers, demotions, or terminations.

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:Education: Bachelor’s degree in Pharmacology, Toxicology, or a related discipline and eighteen years of industry experience; or, Master’s degree in Pharmacology, Toxicology, or a related discipline and sixteen years of industry experience; or, PhD in Pharmacology, Toxicology, or a related discipline and six to nine years of industry experience after post-doctoral trainings; or, Equivalent combination of education and experience. DABT certification

Experience: Experience with IACUC compliance; updating, renewing, amending, and developing new IACUC protocols is essential. Managerial experience related in CRO personnel and in-house PK team is required.Knowledge/Skills: In vivo skills include but not limited to animal handing (in both mice and rats), dosing with different routes (po, iv, sc, ip etc.), blood collection, tissue collection/perfusion, necropsy, clinical observation, and rodent survival surgeries. Broad understanding of PK, PD, Toxicology concepts in the small molecular therapeutics field is essential. Extensive knowledge of preclinical drug development and regulatory filing including authoring and review of relevant sections of regulatory submissions (e.g., INDs, NDAs, BLAs) is required. Proven track records in peer-reviewed publications. Has flexibility to accommodate to fast-paced work environment and deadlines; and ability to work under specific time constraints. Works independently; self-motivated and innovative. Ability to work in a team-based environment and coach junior scientists. Advanced communication skills; written and verbal, presentation skills including ability to communicate scientific information clearly and effectively. Detail oriented and able to problem solve and offer potential solutions. Familiar with conducting pre-clinical PK, TK, Histology and Toxicology studies is must. Comprehensive knowledge of animal biology and physiology including mechanism of action of disease and toxicity. Advanced knowledge of Phoenix 64 WinNonlin, ELN notebook and Graphpad prism is required.

WORKING CONDITIONS: Environment: primarily working in laboratories or in office Exposures encountered, such as hazardous materials Travel not required

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Additional Information

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

  • ID: #22191223
  • State: California Alameda 94501 Alameda USA
  • City: Alameda
  • Salary: USD TBD TBD
  • Job type: Full-time
  • Showed: 2021-11-04
  • Deadline: 2022-01-02
  • Category: Et cetera