Scientist - Functional Genomics

Join Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Scientist - Functional GenomicsWhat you will doLet’s do this. Let’s change the world. In this vital role you will join an enthusiastic, fast-paced team utilizing cutting edge functional genomics and cellular profiling technologies to advance discovery and drug development across Amgen’s therapeutic areas.

Design, develop, and deliver high-dimensional functional genomics screens using advanced perturbation tools and single-cell sequencing assays

Identify and implement new and impactful profiling and screening technologies

Leverage genomics, transcriptomics, epigenomics, and screening data to help develop multi-omic atlases for the characterization of disease biology

Apply computational, statistical, and machine learning methods to analyze internally generated and publicly available omics datasets

Develop strategies and methods to implement disease-relevant model systems for discovery and therapeutic advancement

Maintain organized project records, laboratory notebooks, and code/data repositories

Collaborate closely with disease area, biomarker, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert

Present research findings to cross-functional groups at internal and external meetings and publish scientific findings in peer-reviewed forums

What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.Basic Qualifications:Doctorate degreeORMaster’s degree and 2 years of relevant experienceORBachelor’s degree and 4 years of relevant experiencePreferred Qualifications:

Doctorate degree in genetics, genomics, cell and molecular biology, systems biology, or related disciplines

Demonstrated track record of independent critical thinking, complex problem solving, and innovative research, evidenced by significant contributions to pipeline programs and publications in top tier journals

Hands-on expertise conducting and delivering complex, pooled CRISPR perturbation experiments with a single-cell readout using Perturb-seq, CROP-seq, or similar approaches

Proficiency in programming (e.g. in R/Python), Unix/Linux environments, and cloud computing environments for the analysis of large omics datasets and generation of custom computational pipelines

Proficiency with experimental design, data generation, and analysis principles across a broad range of single-cell/bulk/spatial transcriptomic, epigenomic, and genomic assays

Experience with genomic perturbation at scale using cell lines and primary cells, including approaches such as transient/stable CRISPR-KO/i/a, base editing, and epigenomic modification

Strong written, verbal, and oral communication skills and ability to thrive as a team player in cross-functional settings

What you can expect from usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

Stock-based long-term incentives

Award-winning time-off plans

Flexible work models, including remote and hybrid work arrangements, where possible

Apply nowfor a career that defies imaginationObjects in your future are closer than they appear. Join us.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.