Senior Director, Pharmacogenomics and Bioinformatics

Job Description

The Senior Director, Pharmacogenomics and Bioinformatics, is a highly motivated and accomplished scientific leader who implements the genomic biomarker strategy for the Development-stage product pipeline. Responsibilities include management of computational analyses of clinical and multi-omic data sets to identify potential predictive, prognostic and pharmacodynamic biomarkers. Strategic oversight is provided for companion diagnostic strategies, where applicable.

Qualifications

ESSENTIAL DUTIES AND RESPONSIBILITIES: Build and manage a team of genomic biomarker and bioinformatics scientists Participate in development and implementation of pharmacogenomic and pharmacogenetic assays into company sponsored clinical trials Analyze genomic, cellular, and targeted proteomic biomarker data collected from clinical trials and correlate with clinical outcomes Lead strategy for development of companion diagnostics Collaborate with preclinical and translational pharmacology scientists to develop an early biomarker strategy Collaborate with clinical development, clinical pharmacology, clinical operations, medical affairs, and regulatory affairs in the implementation, interpretation, and reporting of correlative data Communicate findings to project teams, senior management, investigators, and health authorities Collaborate in the review of Investigator Sponsored Trials with correlative components Drive presentation of biomarker data in medical conferences and publication in high quality scientific and medical journals

SUPERVISORY RESPONSIBILITIES: Directly supervise employees. May indirectly supervises employees through a dotted line structure

EDUCATION/EXPERIENCE/SKILLS: Education: PhD in molecular biology, cancer biology, pharmacology or a related discipline and 11 years of related experience; or, Equivalent combination of education and experience.Experience: A minimum of 13 years of experience in the biotechnology or pharmaceutical industry or a combination of academia and industry. Extensive experience in the implementation and interpretation of genomic biomarkers in oncology clinical trials Experience with advanced data analysis tools and approaches

Knowledge/Skills/Abilities: Strong knowledge of molecular and cancer biology Expertise in NGS applications such as WES and RNAseq Applied knowledge of other biomarker approaches such as IHC, flow cytometry and targeted proteomics Experience with big data analysis tools and advanced data analysis techniques Ability to analyze and interpret biomarker data and correlate with oncology clinical trial outcomes Excellent verbal and written communication skills

JOB COMPLEXITY: Expert knowledge of clinical drug development High familiarity with other functional areas in R&D such as Clinical Development, Clinical Pharmacology and Regulatory Affairs Exercises strategic scientific leadership

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Additional Information

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.