Senior Scientist I (Computational Chemistry)

Job Description

Seeking a highly skilled and motivated computational chemist to join our medicinal chemistry drug discovery team. The ideal candidate will be experienced in applying a wide range of molecular modeling and computer aided drug design techniques to the advancement of small molecule drug discovery programs

Qualifications

ESSENTIAL DUTIES AND RESPONSIBILITIES: Work closely with medicinal chemists and project team leaders to drive drug discovery programs from high throughput screening through lead optimization to development candidate selection Triaging of high throughput screening results Devise and implement computational strategies to guide the optimization of small molecules for improved target potencies, selectivity and ADME properties Participation in group, project team and departmental research meetings Compliance with safe laboratory practices and EH&S guidelines Contributes to the writing of technical documents, patents, scientific manuscripts, etc.

SUPERVISORY RESPONSIBILITIES: No supervisory responsibilities

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:Education: Bachelor’s degree in related discipline and twelve years of related experience; or Master’s degree in related discipline and ten years of related experience; or PhD degree in related discipline and zero to three years of related experience; or Equivalent combination of education and experience.

Experience: Extensive theoretical and practical knowledge of structure/ligand-based drug design, cheminformatics, virtual screening, QSAR, pharmacophore development, ligand/receptor docking and predictive modeling. Experience with multiple molecular modeling and cheminformatics platforms (CCG, Molsoft, OpenEye, Schrodinger, Dotmatics, etc.). Expertise in large scale data handling. Programing proficiency in Python, SQL, Java, R. Proven track record of using computational insights to guide medicinal chemistry projects.

Knowledge/Skills: Extensive knowledge of protein structure, homology modeling and protein ligand interaction. Proven track record of problem solving and working and thinking independently. Broad understanding of medicinal chemistry as it applies to lead optimization and Hit-to-Lead campaigns. Excellent at multi-tasking and capable of supporting multiple programs simultaneously. Good interpersonal skills, flexible and works well within a team environment. Excellent written and verbal communication skills. Works in a fast-paced/small-team environment that is growing and evolving and which requires regular reprioritization of projects while adhering to timelines and achievement of deliverables. Has an in-depth knowledge of the functional area. Exercises independent judgment in methods, techniques and evaluation of criteria for obtaining results.

WORKING CONDITIONS: Environment: primarily working in laboratories or in office Travel not required

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Additional Information

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.