Technology Mgr - Assay Development

Job Description

To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Team is seeking a highly motivated Technical Leader (Manager) to help lead teams to test and validate novel technologies for rare variant studies with next-generation sequencing in a highly regulated environment. At Guardant, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.

As aTechnical Leader (Manager) in the Technology Development Team, you will work with members within the team and interface with multiple teams including process engineering, clinical operations, research operations, and bioinformatics. You will be required to design, implement, and validate new technologies with rigorous documentation practices related to liquid biopsy sequencing assays for the early detection, treatment, and monitoring of all cancer types. You will also be an experienced leader with abilities to keep timelines on track within project teams of direct and indirect reports.

• Be able to work in a team environment and independently to develop, test and validate technologies for rare variant studies with next-generation sequencing with rigorous and thorough documentation practices
• Think creatively and apply knowledge to design validation experiments and analyze data for NGS applications in oncology diagnostics
• Document product development requirements and system and subsystem level verification and validation protocols and results
• Be highly committed and deliver results in a fast-paced start-up environment
• Be a committed and experienced leader in the IVD diagnostics space

Qualifications

• 15+ years of experience in genomics or molecular biology, preferably developing IVDs
• Experience with development under a FDA regulated environment (i.e. Design control) is a must
• Experience optimizing, developing, or validating droplet digital PCR is a plus
• Comprehensive knowledge of sample preparation and sequencing technologies
• Strong background in molecular biology
• Experience in development or optimization of nucleic acid technologies with a strong preference related to sequencing-based genomic assays, preferably in regulated environments.
• Deep technical knowledge of NGS library preparation, target enrichment, and rigorous product development practices
• Experience with bioinformatics analysis of NGS data is a plus, required to have working knowledge of types of bioinformatics analysis performed for NGS-based diagnostics
• Excellent interdisciplinary communication skills required
• Good organization skills, and detailed orientated
• Self-driven and strong team player with proven track record
• MS or PhD in Molecular Biology, Genetics, Biochemistry or related field
• Strong preference given to local candidates

Additional Information

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

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