Director, Translational Sciences and Diagnostics

The Translational Sciences and Diagnostics department is looking to hire a Director to support and oversee the development and execution of Translational strategies for our emerging pipeline of preclinical Bicycle Drug and Radio-conjugate programs. In collaboration with our Research and Innovation (R&I) colleagues, the successful candidate will be responsible for advising on target selection, developing predictive and pharmacodynamic (PD) biomarker strategies, including developing PK-PD-E modelling, and investing in clinical biomarker assay development to support pre-clinical assets from concept to Candidate Selection. Execution of the duties of this role will require co-ordination of activities supporting biomarker strategies internally within and across the Translational Sciences and R&I departments as well as managing scientific studies with a range of CRO’s, external collaborators and clinical investigators. The aim of these studies will be to gain a deep understanding of portfolio asset MOA alongside development of patient stratification and/or PD biomarkers. This position will report to the SVP of Translational Sciences & Diagnostics.Contribute to early development of the Bicycle discovery pipeline as the Translational team representative for all preclinical programs as well as new target identification effortsOwn development and implementation of biomarker strategies for all preclinical Bicycle Drug and Radio-conjugate programsIdentify pharmacodynamic assays for utility in pre-clinical and future clinical testing to help define PK/PD/efficacy relationships.Lead primary analyses of pre-clinical translational biomarker studies, including evaluation of patient selection strategiesAuthor and review the translational sections of regulatory documents (IND, clinical protocols) as well as scientific/clinical publications and present pre-clinical translational findings at scientific congressesDevelop effective working relationships across the Translational Sciences and R&I departments to manage diverse scientific studies with internal teams, CRO’s and external collaboratorsAdditional responsibilities as needed and directed