Scientist – Off-Target Genomics (Gene Therapy)

We are seeking a Scientist – Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects, genomic integrity, and emerging genome editing modalities.Key Responsibilities:Lead genomic safety assessment packages, including off-target discovery, verification, validation, and genomic integrity characterizationApply and evaluate off-target discovery approaches using:In silico tools (e.g., CALITAS, CRISPRme, Cas-OFFinder)Biochemical methods (e.g., SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq)Cell-based assays (e.g., GUIDE-seq, INDUCE-seq)Drive off-target confirmation using sequencing-based approaches such as AmpSeq, rhAmpSeq, and hybrid captureAssess genomic integrity using orthogonal platforms including karyotyping, optical genome mapping, and whole genome sequencing (WGS)Evaluate genotoxicity risks associated with next-generation genome editing technologies, including base and prime editingSupport and/or lead development of novel assays for emerging genome editing modalities (Gen 5+)Integrate biodistribution data to inform tissue selection for off-target verification studiesCollaborate cross-functionally and present findings clearly to scientific and project teams