Postdoctoral Fellow-MSH-32074-054

Job DescriptionJob Description TemplateTitle: Postdoctoral Research FellowSalary: $73,588Department: Cardiovascular Research InstitutePhysical work location:1470 Madison Ave.Hess CSM 7 th Floor, Room 202New York, NY, 10024Name PI or Supervisor: Filip Swirski, filip.swirski@mssm.edu , 212-824-8901Web link to Lab: https://labs.icahn.mssm.edu/swirskilab/Web link to Department: https://icahn.mssm.edu/research/cardiovascularAdministrative Contact: Christopher Chan, Christopher.chan@mssm.edu , 212-824-9897QualificationsTechnical Duties:Wet laboratory duties include: Animal handling, microbiology, cell biology, molecular biology, animal microsurgery, imaging. Dry laboratory tasks include: bioinformatics, data analysis, manuscript preparation, project presentation (talks/posters).Educational and other Requirements for the position: PhD, MD, or PhD/MDExperience Required: N/AGoals/Outcomes of the Research Project: This project will explore which and how specific neurons in the braincontrol atherosclerosis-regulated hematopoiesis and demonstrate the impact of manipulation of these brain regions on the development of atherosclerosis. This project could lead to the discovery of conceptually new therapeutic approaches for the treatment of atherosclerosis.Compensation StatementThe Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits., J16 - Cardiovascular Research Institute - ISM, Icahn School of MedicineEOE Minorities/Women/Disabled/VeteransThe Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”ResponsibilitiesTitle: Central nervous system control of hematopoesis in atherosclerosis.Atherosclerosis and acute myocardial infarction (MI) as its major life-threatening complication are major causes of overall morbidity and mortality in industrialized countries. Atherosclerosis is a chronic inflammatory disease developing in response to intimal lipid deposition, involving and mediated by pro-inflammatory processes driven by vascular recruitment of various immune cells. Leukocytes both contribute to all stages of atherosclerosis and to tissue healing and remodeling following MI. Recent studies demonstrated that atherosclerosis and MI influence myelopoiesis in the bone marrow, resulting in monocytosis and neutrophilia and subsequently increased recruitment of these cells to the growing lesion and to the infarcted myocardium. Importantly, specific regions in the brain such as the corticotropin releasing hormone (CRH) producing neurons in periventricular hypothalamus (PVH) control peripheral immune cell numbers and function and can induce large scale leukocyte shifts and functional alterations in the blood. In addition, manipulating stress centers in the brain during myocardial infarction dampens inflammation and improves healing. Collectively, these data suggest that the brain may regulate the interplay between hematopoesis and atherosclerosis, however the underlying mechanisms remain literally unexplored. We hypothesize that increased hematopoiesis during atherosclerosis is controlled by specific regions and activity patterns in the central nervous system. We aim to (1) identify regional and cellular brain activity patterns in mice with atherosclerosis, and (2) target these brain regions in mice with and without atherosclerosis.About UsStrength Through DiversityThe Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.Explore more about this opportunity and how you can help us write a new chapter in our history!“About the Mount Sinai Health System:Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”EOE Minorities/Women/Disabled/VeteransCompensation StatementMount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.