Senior Scientist – Discovery Vaccine Bioanalytics

Job RequirementsWe are seeking a highly motivated Senior Scientist to join the Discovery and Translational team within Pre-Clinical Development Regulated Bioanalytics at West Point. The primary role of the successful candidate will be to design and develop immunology-based bioanalytical assays in support of early vaccine programs. The individual will be responsible to contribute with limited supervision to all aspects of assay development, technology transfer, and/or troubleshooting. The ideal candidate will have solid laboratory experience in the field of immunology and/or cell biology, a broad skill set encompassing working with primary immune cells to developing bioanalytical assays capable to meet clinical assay requirement. The candidate should be current on state-of-the art technologies and is expected to champion evaluation of new technologies and optimize processes. Providing expert technical representation on multidisciplinary teams will be expected.Responsibilities

Provide scientific input to the design and execution of ligand binding assays (LBA) such as ELISA and/or cell-based assays such as luciferase reporter assays

Responsible for the execution of method development, troubleshooting and/or pre-clinical/clinical sample analysis as needed

Contribute to the assessment and implementation of new analytical technologies

Serve as an internal subject matter expert on developed assays

Accountability for generated the data

Work ExperienceEducation Minimum Requirement:PhD in Biological Sciences or related area with 0-3 years, or a MS degree with 4+ years, or a BS degree with 7+ yearsRequired Skills:

Critical thinking and good trouble-shooting skills

Experience in general cell biology methods including maintenance of cell lines and/or primary cells

Experience with immunoassays such as ELISA, AlphaLisa, multiplexed LBA on MSD and/or Luminex platforms

Adherence to basic safety procedures in a BSL2 laboratory

Good verbal and written communication

Ability to follow procedures and thoroughly document experiments

Communicate results effectively in presentations to stakeholders in partner organizations or at external scientific meetings, to write technical reports, and to participate on cross-functional teams

Preferred Experience and Skills:

Experience with cell-based assays in the context of immune response characterization such as viral neutralization, PRNT/VRNT/FRNT, ELISpot, or multi-color flow cytometry

Prior experience with PBMC isolation, human and/or mouse tumor tissue processing

Experience in molecular biology technique such as DNA and RNA isolation, qPCR, digital PCR, RNAseq, NGS, or CRISPR

Familiarity with liquid handlers and other automation platforms for sample preparation and assay process

Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously

#PCDBioAnalyticalRequisition ID: P-100545